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Vaccination with purified Dr Fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin.

Goluszko P, Goluszko E, Nowicki B, Nowicki S, Popov V, Wang HQ

University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1062, USA. pgoluszk@utmb.edu

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

Published 24 December 2004 in Infect Immun, 73(1): 627-31.
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