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Oxidative stress in children with kidney disease.

Pavlova EL, Lilova MI, Savov VM

Medical Physics, Faculty of Physics, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164, Sofia, Bulgaria, elli_pavlova@abv.bg.

The aim of this work was to study the dynamics of oxidative stress in the blood and urine of children with kidney diseases: glomerulonephritis (GN), pyelonephritis (PN), renal failure (RF), and lower urinary tract infections (LUTI). The concentration of conjugated dienes is increased in blood: GN 4 times and RF up to 2 times; and extremely increased in urine: GN 12 times and RF 4 times. The concentration of thiobarbituric acid reactive substances in urine shows a similar trend: GN 7 times, PN 2 times, RF 1.5 times, and LUTI almost 3 times. Urine chemiluminescence is also increased: GN 5 times, PN and LUTI 3 times, and RF 6 times. Kidney disease leads to 2.5-fold inhibition of antioxidant catalase activity in blood and 10-fold in urine. Total antioxidant activity of urine is induced in all groups: GN 18 times, PN 2 times, RF 1.5 times, and almost 4 times in the LUTI group. Experimental data confirm that products of lipid peroxidation, intensity of chemiluminescence, and total and enzyme antioxidant capacity in combination with clinical parameters are a proper test for the dynamics of oxidative stress and markers of intoxication in children with inflammatory and immunological active parenchymal kidney disorders. These data could be helpful for the optimization of complex and effective antioxidant therapy of children with kidney disease.

Published 6 October 2005 in Pediatr Nephrol, 20(11): 1599-604.
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