Cranberry Research Today is a free monthly online journal that collates and summarizes the latest research about Cranberry, including details on benefits, antioxidants, utis, cystitis.

Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

Bowser TE, Bartlett VJ, Grier MC, Verma AK, Warchol T, Levy SB, Alekshun MN

Paratek Pharmaceuticals, Inc., 75 Kneeland Street, Boston, MA 02111, USA. tbowser@paratekpharm.com

Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.

Published 18 September 2007 in Bioorg Med Chem Lett, 17(20): 5652-5.
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