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Fluoroquinolone-resistant uropathogenic Escherichia coli in Norway: evidence of clonal spread.

Grude N, Strand L, Mykland H, Nowrouzian FL, Nyhus J, Jenkins A, Kristiansen BE

Department of Medical Microbiology, Telemark Biomedical Centre, Skien, Norway. nils.grude@telelab.no

Prevalence, resistance profiles, virulence gene complements, and phylogenetic and clonal affinities of fluoroquinolone-resistant Escherichia coli from urinary tract infections (UTIs) in Norway were investigated. Of 7302 E. coli UTI isolates from 2003, 1.2% were fluoroquinolone-resistant; 35 of these fluoroquinolone-resistant isolates were included in the present study. The isolates were predominantly multiresistant, carried few virulence factors, and tended to belong to the less-virulent phylogroups A and B1. Although the isolates were genetically heterogeneous, there was evidence of a limited degree of clonal dissemination.

Published 10 April 2008 in Clin Microbiol Infect, 14(5): 498-500.
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